Application of 611-09-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 611-09-6, name is 5-Nitroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of substituted isatins (1 mmol),cyclic 1,3-diketone (1 mmol), malononitrile (1 mmol)and nano Ag/kaolin (0.085 g, 7 mol%) in EtOH (10mL) was stirred at reflux temperature. Uponcompletion instead of compilation, monitored by TLC(n-hexane/ethyl acetate: 2/1), the reaction mixture wasallowed to cool to room temperature. The catalyst wasseparated by filtration of this solution. The solution wasconcentrated under vacuum to afford the product,which was purified by recrystallization in the ethanol.All the products were identified by comparing of meltingpoint and 1H NMR spectra with those of authenticsamples reported in the literature.2- Amino -5′ – Nitro -2 ‘ , 5- Ioxo -5 , 6 , 7 , 8 -Tetrahydrospiro[Chrom-ene-4,3’-Indoline]-3-Carbonitrile (4c).m.p. 283-285 C; 1H NMR (400 MHz,DMSO-d6) : 1.79 -2.02 (m, 2H, CH2), 2.22-2.26 (m,2H, CH2), 2.62-2.69 (m, 2H, CH2), 7.03 (d, J=8.6Hz, 1H), 7.40 (brs, 2H, NH2), 7.87 (s, 1H, ArH), 8.13(d, J= 6.22 Hz, 1H, ArH), 11.17 (s, 1H, NH).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Sadeghi, Bahareh; Lasemi, Zahra; Azimi, Razieh; Oriental Journal of Chemistry; vol. 31; 2; (2015); p. 1175 – 1179;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem