Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1914-02-9, name is 3,3-Dimethylindoline, A new synthetic method of this compound is introduced below., COA of Formula: C10H13N
General procedure: A mixture of 24.5 mg (0.18 mmol) 1,2,3,4-tetrahydroquinoline, 37.3 mg (0.188 mmol) 1-adamatanecarbonyl chloride and 44.4 mg (0.34 mmol) DIPEA in 1 mL DCM was shaken at room temperature for 4 h. The mixture was evaporated, dissolved in DMF and subjected to column chromatography on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid to yield after evaporation of the product containing fractions 34.9 mg (64%) of the title compound as white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Nettekoven, Matthias; Fingerle, Juergen; Grether, Uwe; Gruener, Sabine; Kimbara, Atsushi; Puellmann, Bernd; Rogers-Evans, Mark; Roever, Stephan; Schuler, Franz; Schulz-Gasch, Tanja; Ullmer, Christoph; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1177 – 1181;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem