Related Products of 19727-83-4, A common heterocyclic compound, 19727-83-4, name is 6-Nitroindoline, molecular formula is C8H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
9.84 g (0.06 mol) of 6-nitro-2,3-dihydro-1H-indole (16) was dispersed in 100 ml of dichloromethane under a nitrogen atmosphere, stirred at room temperature for about 10 minutes,11.8 g (0.12 mol) of cyclohexanone, 8.6 ml (0.15 mol) of acetic acid,29.7 g (0.14 mol) of sodium triacetoxy borohydride were added in this order, and the reaction solution was reacted at room temperature for 4 hours.200 ml of 1 N aqueous sodium hydroxide solution was slowly added to the reaction mixture, and the mixture was stirred for 30 minutes. The organic layer was separated, washed with H2O,The recovered organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The resulting product was dispersed in 100 ml of methanol, stirred at room temperature for 30 minutes, filtered and dried to obtain 6-nitro-2,3-dihydro -1-cyclohexyl-1H-indole (55) (12.7 g, 86.0%).
The synthetic route of 19727-83-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Korea Research Institute of Chemical Technology; Shin Seung-rim; Jeon Geun; Shin Jong-il; Park Yeong-il; Ahn Gyeong-ryong; (48 pag.)KR101842495; (2018); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem