Some common heterocyclic compound, 675109-26-9, name is 6-Bromoisoindolin-1-one, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 675109-26-9
O2O3] &bromoisoindolin4-orse (1050 mg, SM m.mol% copper powder (32 mg, 0.5 mmol) and methylamine (40% in F120, 2.7 mL) were placed in a pressure vess& and the sealed reaction was heated at 105 C overnight. The reaction mixture was poured into ethyl acetate (150 niL) and washed with saturated NH4CI solution. The organic layer was dried over sodium sulfate, filtered and concenflted. The volatile was removed in vacua and the residue was then purified by silica gel chromatography eluting with MeOH and dichloromethane Rf 0.2, 5% MeOH in DCIVO to afford 300mg of the title compound. MS (m/z): 163.13 [M+H]t HPLC retention time 0.17 mm (248% acetonitrile: water with 0.05% trifluoroacetie acid). ?H NMR (400 MHz, dmso) 8 8.28 (s 1K), 7.20 (d, J= 8.2 Hz, 1H), 6.75 (dd, J 8.2, 2.2 Hz5 lH), 6.68 (d, J= 2.1 Hz, 1K), 5.83 (d, J 5.0 Hz, IH), 4.15 (s, 2K), 2.66 (d, J= 5,1 Hz, 3Ff).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 675109-26-9, its application will become more common.
Reference:
Patent; GILEAD SCIENCES, INC.; BONDY, Steven, S.; CHOU, Chien-Hung; LINK, John, O.; TSE, Winston, C.; WO2015/130964; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem