Application of 101207-45-8,Some common heterocyclic compound, 101207-45-8, name is 2-(4-Methylbenzyl)isoindoline-1,3-dione, molecular formula is C16H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 251 mg of 2- (4-methylbenzyl) isoindolin-1,3-dione (1 mmol), 12 mg of potassium methoxide to a glass test tube with magnetons, add 2 ml of isopropanol under nitrogen protection, add 2 microliters of 0.01M catalyst (S / C = 50,000), filled with 4 MPa hydrogen, and reacted at 40 C for 24 hours. After the reaction, the reaction mixture was naturally cooled to room temperature, and the hydrogen gas was carefully released. The celite was filtered, and the organic solvent was removed from the filtrate to obtain 249 mg of the product in a yield of 98%
The synthetic route of 101207-45-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; South University of Science and Technology of China; Ma Baode; Shao Panlin; Wu Chao; Wang Jiang; Zhang Xumu; (12 pag.)CN110746342; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem