Reference of 446292-08-6, These common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
9 g (0.021 mol) of 2-({(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1 ,3-oxazolidin-5- yl}methyl)-1 H-isoindole-1 ,3(2H)-dione (II), 8.06 mL of methylamineamine (40% aqueous solution, 0.235 mol) and 80 mL of ethanol were charged in a 100 mL flask and the reaction mixture was heated to 65 C for 2h. Then, 10 mL of a 20% HCI solution was added until the pH of the reaction mass was adjusted to 2.7. The reaction mass was cooled to 30 C and the resulting solid was filtered off, washed with ethanol and dried under vacuum at 60 C.Yield: 5.3 g. Molar yield: 75.7%. HPLC purity: 93.9%
The synthetic route of 446292-08-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS LESVI, S. L.; VISHNU NEWADKAR, Ravindranath; CHANGDEO GAIKWAD, Avinash; MADHUKAR HARAD, Ajay; DALMASES BARJOAN, Pere; WO2013/53739; (2013); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem