Some common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, molecular formula is C10H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2913-97-5
Aldehyde reaction partner selection was key in order to assign donor and acceptor roles to aldehydes in the previously discussed aldol reaction. Aldol reactions between Compound 1 and oc-non-branched aldehydes such as isovaleraldehyde and hexanal afforded P-hydroxy-y- (diprotected) amino aldehydes Compounds 6 under identical conditions to those used in Table 5 (see, Scheme 10, hereinbelow, wherein R is a non-branched substituent containing at least two hydrogen atoms) . No formation of (3-hydroxy-a-amino aldehydes was detected. In these instances, aldehyde Compound 1 acted as the acceptor. Slow addition of aldehyde Compound 1 to isovaleraldehyde in thepresence of the catalyst did not change the outcome of the reaction.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2913-97-5, its application will become more common.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2006/23720; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem