Related Products of 21857-45-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21857-45-4, name is 5-Methoxyindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step B : 5-methoxy-1-nitroso-2,3-dihydro-1H-indole; To 10 ml of 50% acetic acid solution at 0 C. there is added, all at once, 0.499 g of the compound of Step A above. At 0 C., 0.232 g of sodium nitrite dissolved in 5 ml of water is added dropwise. Once the addition is complete, the reaction mixture is stirred at 0 C. for 1 hour 30 minutes. After adding water, the aqueous phase is extracted 3 times with dichloromethane; the combined organic phases are washed with water and dried over magnesium sulphate. Evaporation to dryness yields the expected product, which is used in the subsequent reaction without purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methoxyindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LES LABORATOIRES SERVIER; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE PARIS SUD; US2009/176794; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem