Reference of 5332-26-3,Some common heterocyclic compound, 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Appropriate bromide (1.5 mmol) was dissolved in 15 mL of DMF (dried) and sodium azide (1.6 mmol, 104 mg) was added. The mixture was stirred vigorously at room temperature. After 12 h the reaction was quenched by adding 15 mL of distilled water (slightly exothermic reaction). The cooled reaction mixture (room temperature) was extracted twice with 30 mL of diethyl ether and washed with water (once with 20 mL). The separated organic layer was dried over anhydrous sodium sulphate and evaporated to dryness. The product obtained as white solid was washed with 30mL of distilled water.
The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pyta, Krystian; Klich, Katarzyna; Domagalska, Joanna; Przybylski, Piotr; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 651 – 676;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem