The important role of 101207-45-8

Electric Literature of 101207-45-8, A common heterocyclic compound, 101207-45-8, name is 2-(4-Methylbenzyl)isoindoline-1,3-dione, molecular formula is C16H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Electric Literature of 101207-45-8, A common heterocyclic compound, 101207-45-8, name is 2-(4-Methylbenzyl)isoindoline-1,3-dione, molecular formula is C16H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis Intermediate 4 Dissolve 12.3g of 2-(4-methylbenzyl)-1H-isoindole-1,3-dione in chloroform, then add 8.7g of chlorosulfonic acid, Reaction at 80C for 3h; after the reaction, After washing with water and removing the solvent, 15.75 g of Intermediate 4 was obtained with a yield of 95%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhengzhou Shouxing Pharmaceutical Institute Co., Ltd.; Deng Zhaoxi; (11 pag.)CN110627706; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem