Reference of 1677-48-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1677-48-1, name is 5,6-Dichloroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 2a 2-(6,7-dichloroisatin-1-yl)acetic acid (2c). A solution of 5,6-dichloroisatin (1.0 g, 4.65 mmol) in DMF (20 ml) was cooled in an ice-bath. Sodium hydride (5.11 mmol, 0.20 g 60% dispersion in mineral oil) was added and the mixture was stirred for 20 min. Ethyl 2-bromoacetate (0.37 ml, 5.11 mmol) was added and stirring was continued for 2 hours. The resulting mixture was poured into diluted hydrochloric acid (200 ml, 4 M), heated to reflux for 2 hours, filtered, cooled and extracted with ethyl acetate. The organic extract was dried over magnesium sulphate and evaporated to dryness to leave the desired product (0.85 g, 67%).
The synthetic route of 5,6-Dichloroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jensen, Bo Skaaning; Jorgensen, Tino Dyhring; Ahring, Philip K.; Christophersen, Palle; Strobaek, Dorte; Teuber, Lene; Olesen, Soren Peter; US2002/16354; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem