Adding a certain compound to certain chemical reactions, such as: 320734-35-8, name is 7-Bromooxindole, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 320734-35-8, HPLC of Formula: C8H6BrNO
To a solution of 7-bromo-l ,3-dihydro-2H-indol-2-one (200 mg, 0.94 mmol) in DMF (5 mL) were added cesium carbonate (676 mg, 2.07 mmol) and iodomethane (294 mg, 2.07 mmol). The reaction mixture was stirred at ambient temperature for 18 h, then partitioned between H2O (50 mL) and EtOAc (100 mL). The organic extract was dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of hexane: EtOAc – 100:0 to 85: 15, to give the title compound. MS: m/z = 254 (M + 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromooxindole, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2006/31513; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem