Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112656-95-8, name is 7-Nitroindoline-2,3-dione, A new synthetic method of this compound is introduced below., name: 7-Nitroindoline-2,3-dione
The solution of 7-nitroisatin (15) (1 g, 0.005 mol), malonic acid (0.54 g, 0.005 mol) and piperidine (0.10 ml) in pyridine (10 ml) was refluxed for 50 hours. After cooling to room temperature, the precipitate was collected by vacuum filtration, washed with small amount of solution of hydrochloric acid in 1,4-dioxane (16%) and water, dried on air to give 0.38 g (31 % yield) of (7-nitro-2-oxindole-3-yliden)acetic acid. mp (exp.) = 220-225 0C. Spectrum NMR 1 (DMSO-d6, delta, ppm, J, Hz): 7.06 (s, 1H), 7.45 (t, J = 7.96, 1H), 8.44 (d, J = 7.96, 1H), 8.56 (d, J = 7.83, 1H), 11.32 (s, 1H). Spectrum NMR 13C (DMSO-d6, delta, ppm): 99.98; 118.43; 122.32; 124.37; 128.48; 128.83; 134.26; 141.89; 166.54. IR spectrum (sm-1): 1306; 1348; 1379 (C=C-H), 1531; 1593 (NO2), 1633 (C=O), 1709 (C=O), 3075 (C=O), 3280 (C=O). MS (EI, 70 eV), m/z (I, %): 234 (100, M+), 204 (29), 176 (7), 160 (7), 142 (10), 114 (22), 104 (15), 88 (10), 63 (9), 45 (20), 30 (29).
The synthetic route of 112656-95-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zaryanova, Ekaterina V.; Lozinskaya, Nataly A.; Beznos, Olga V.; Volkova, Maria S.; Chesnokova, Nataly B.; Zefirov, Nikolay S.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 16; (2017); p. 3787 – 3793;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem