Application of 6941-75-9, These common heterocyclic compound, 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 25: Synthesis of dimethyl-(6-phenylaminomethyl-phthalazin-l-yl)-amine; 5-Bromo-3-hydroxy-2,3-dihydro-isoindol-l-oneA mixture of zinc powder (8.68 g, 132.7 mmol), copper (II) sulfate pentahydrate(0.11 g, 0.44 mmol) and aqueous sodium hydroxide (135 mL, 2M solution) were cooled to 0 0C. Bromophthalimide (25 g, 110.6 mmol) was added in portions over 30 minutes, maintaining the temperature at 0 0C. The reaction was stirred at 0 0C for 30 minutes, and at room temperature for 3 h. The reaction was filtered, neutralized to pH 7 with concentrated HCl, diluted with EtOH, and then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the desired compound (15.75 g, 63 %) as a colourless solid.
Statistics shows that 5-Bromoisoindoline-1,3-dione is playing an increasingly important role. we look forward to future research findings about 6941-75-9.
Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; WO2008/61108; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem