550-44-7, name is 2-Methylisoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 550-44-7
(1) Refer to Figure 2 to determine the microchannel reactor connection mode, remove the preheating zone module, the channel type is cylindrical straight channel and circular microchannel structure, the number of microchannel mixed reaction modules is determined according to the flow rate and residence time.The N-methylphthalimide-concentrated sulfuric acid solution was regarded as the raw material A, the concentrated nitric acid solution was regarded as the raw material B, and the two materials were injected into the reaction zone through the metering pump at a flow rate of 10 ml/min and 25 ml/min, respectively. In the mixed residence reaction, the molar ratio of concentrated nitric acid to substrate is 1.2:1, the mass ratio of substrate to concentrated sulfuric acid is 1:2, and the microchannel reactor of Fig. 2 is used to control the temperature of 60 C, residence time. 180s, the reaction solution was quantitatively collected, washed with ice water, washed with water, filtered, and dried to obtain N-methyl-4-nitrophthalimide nitrated product, HPLC content analysis (normalized) 97%, yield 96 %.
The synthetic route of 550-44-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Wanfeng Chemical Co., Ltd.; Liu Tao; Yao Chenhua; Yu Xingying; Yu Xiaotian; (11 pag.)CN109305933; (2019); A;,
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