Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2307-00-8, name is 5-Amino-2-methylisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., category: indolines-derivatives
4-N-Ethylamino-N-methylphthalimide (5) A mixture of 10 g (0.057 mol) of 4-amino-N-methylphthalimide (4) [Flitsch, Chem. Ber. 94:2494(1961)], 17.5 g (0.11 mol) of diethyl sulfate, and 100 ml of 2,2,2-trifluoroethanol was refluxed for one day. The reaction mixture was cooled, concentrated under reduced pressure, and the residue partitioned between 250 ml of ethyl acetate and 100 ml of saturated sodium bicarbonate solution containing 10 ml of triethylamine. The ethyl acetate phase was separated, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and evaporated. The residue was recrystallized twice from acetone-hexane and then from aqueous methanol to give 3.4 g (29% yield) of the phthalimide (5) as fine yellow crystals, m.p. 157 C. Analysis: Calculated for C11 H12 N2 O2: C, 64.69; H, 5.92; N, 13.71. Found: C, 64.00; H, 5.71; N, 13.37. NMR Spectrum (C5 D5 N): delta 0.5 (t, J=7 Hz, 3H), 2.1 (s, 3H).
The synthetic route of 2307-00-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Miles Laboratories, Inc.; US4261893; (1981); A;,
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