Synthetic Route of 1336963-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1336963-95-1, name is 6-Bromo-7-fluoroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example Dl, Step 3. To a solution of the 6-bromoindoline-2,3-dione (e.g., 6-bromo-7- fluoroindoline-2,3-dione, 1 equiv) in 1 Nu NaOH (0.14 M) was added H202 (1.8 M) dropwise and the resulting mixture was stirred at room temperature until the reaction was complete (approximately 2 hours). The mixture was filtered and the filtrate was acidified to pH 2 with hydrochloric acid. The precipitate that formed was filtered, washed with water, and concentrated to provide the 2-amino-4-bromobenzoic acid (e.g., 2-amino-4-bromo-3-fluorobenzoic acid).
The synthetic route of 6-Bromo-7-fluoroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HEFFERNAN, Michele, L., R.; HARDY, Larry, Wendell; WU, Frank, Xinhe; SARASWAT, Lakshmi, D.; SPEAR, Kerry, L.; WO2012/170845; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem