Application of 21544-81-0, The chemical industry reduces the impact on the environment during synthesis 21544-81-0, name is 4,6-Dimethoxyindoline-2,3-dione, I believe this compound will play a more active role in future production and life.
EXAMPLE 2 4,6-dimethoxyanthranilic acid To a heated mixture (in an oversized flask) of 13 g (63 mmol) 4,6-dimethoxyindole-2,3-dione prepared in Example 1 and 108 ml of 33% NaOH solution was carefully added 20 ml of a 30% solution of H2O2. A vigorous exothermic reaction occurs. After all H2O2 was added, the reaction mixture was maintained at 100 C. for an additional 10 min. The pH of the solution was brought to 8 with concentrated HCl and acidified to pH 5-6 with acetic acid. The solid was filtered, washed with water and dried to yield 6.2 g of 4,6-dimethoxyanthranilic acid as a pale brown solid (50% yield). C9H11NO4=197.19 g/mol; HPLC purity=100%; ESI-LC/MS (M+H)+=198.: MP:120-125 C.; 1H NMR (400 MHz, DMSO-d6): delta5.94 (d, J=1.76 Hz, 1H), 5.79 (d, J=1.76 Hz, 1H), 3.75 (s, 3H), 3.71 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Dimethoxyindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gungor, Timur; Corte, James R.; US2003/220227; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem