Reference of 56341-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56341-37-8 name is 6-Chlorooxindole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 3Preparation of 6-chloro-5-(chloroacetyl) oxindole :Charged with 500 ml of ethylene dichloride and A1C13 (250gm) in a 3 litre there-neck flask under nitrogen atmosphere at 25 to 30C. Add 84.19 gm of chloroacetyl chloride slowly at RT controlling the exotherm and stirred for 30 minutes.Contents are further added with 100 gm of 6- chloro-oxindoie at 35-37C in an hour. Stirring is continued at 35-37C for 10-12 hrs.Cool gradually to 0 to 5C and pour into ice, and water under stirring over 30 minutes. Stir for 30 minutes, remove ethylene dichloride by distlation under vacuum, cool the mass and filter off the product wash with water till it is neutral. Purify the product using 1,4- dioxane if required.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chlorooxindole, and friends who are interested can also refer to it.
Reference:
Patent; ARCH PHARMALABS LIMITED; GHOGARE, Bhausaheb Nana; DESHPANDE, Uday K.; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; CHARANJIT, Sehgal; NEHA, Dixit Akshaya; WO2012/20424; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem