Some tips on 2058-74-4

Some common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Methylisatin

Some common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Methylisatin

General procedure: First phenyl acetylene (1 mmol) was stirred with Et3N (1 mmol) in CH3CN (5 mL) at room temperature. After 15-20 min, N-methyl isatin (1 mmol) and InBr3 (15 mol%) was added and the reaction mixture was stirred for 16-18h. When N-methyl isatin was completely consumed as indicated by TLC, phenacyl bromide (1 mmol) was added and the reaction mixture was stirred until the reaction reached completion, as evidenced by TLC. Acetonitrile was distilled out under reduced pressure and the residue was purified by silica gel (mesh 60-120) chromatography (hexane-EtOAc) to afford the corresponding products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2058-74-4, its application will become more common.

Reference:
Article; Siddiqui; Rahila; Shamim, Shayna; Rai, Pragati; Shireen; Waseem, Malik A.; Abumhdi, Afaf A.H.; Tetrahedron Letters; vol. 54; 51; (2013); p. 6991 – 6994;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem