Electric Literature of 5332-26-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Dried C6H5-closo-1,2-C2B10H12 2.00 g (9.06 mmol) was dissolved in DME (40 ml) under argon, the solution was then cooled down to -33 C. and BuLi (2.5 M in hexane, 4.0 ml, 10,0 mmol) was added dropwise from a syringe. The reaction mixture was stirred for additional 15 min., then left to warm up to room temperature and cooled down again to -33 C., solution of bromopropyl phtalimide in DME (15 ml) was added slowly, reaction mixture was then kept at low temperature for 15 min. and then left to warm slowly under stirring to room temperature over 4 h and left to stand overnight. Solids were removed by filtration under argon and washed with DME (2×10 ml). Diluted acetic acid (3 M, 0.5 ml) was added to filtrate and the volatiles were removed in vacuum. Solids were dissolved in benzene and the injected atop of a silica gel column (25×3 cm I.D.). The unreacted starting compound (440 mg, 22%) was eluted by benzene, whereas the propyl phtalimide intermediate was isolated by elution with benzene-CH3CN (95:5) and evaporated to dryness; yield 1.95 g (53%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Bromomethyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERZITA PALACKEHO V OLOMOUCI; USTAV ORGANICKE CHEMIE A BIOCHEME AKADEMIE VED CESKE REPUBLIKY, v.v.i.; USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, v.v.i; Brynda, Jiri; Cigler, Petr; Gruner, Bohumir; Maloy Rezacova, Pavlina; Mader, Pavel; Sicha, Vaclav; Bakardjiev, Mario; Holub, Josef; Dzubak, Petr; Hajduch, Marian; US2014/303390; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem