Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21857-45-4, name is 5-Methoxyindoline, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Methoxyindoline
0 degree celcius at the 5-methoxy indoline (257mg, 1.72mmol) and triethylamine (487ul, 3.44mmol) was added to dichloromethane (8.0mL), and then slowly added 4-methoxy-3- (4- (2,2,2-trichloro-acetyl) piperazin-1-yl) benzene-1-sulfonyl chloride (500mg, 1.15mmol). After 10 minutes the reaction temperature was raised to 25 , the reaction overnight. Was added 50mL of dichloromethane and then with saturated sodium chloride solution (40 mL), the organic phase after separation was dried over anhydrous sodium sulfate. Filtered, the filtrate was spin dry, purified by column chromatography (petroleum ether / ethyl acetate (v / v) = 5/1) to give the title compound as a white solid (554mg, 87.9%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 21857-45-4.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Zhang, Wenhe; Jin, Chuanfei; Zhang, Yingjjun; Zhang, Ji; (50 pag.)CN105367474; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem