Introduction of a new synthetic route about 6872-06-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6872-06-6, name is 2-Methylindoline, A new synthetic method of this compound is introduced below., Safety of 2-Methylindoline

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6872-06-6, name is 2-Methylindoline, A new synthetic method of this compound is introduced below., Safety of 2-Methylindoline

Preparation 2 Synthesis of N-trifluoroacetyl-2-methylindoline-5-sulfonylchloride 2-Methylindoline (10mlitre, 76.8mmol) was dissolved in 100mlitre of dichloromethane and then cooled down to 0C. To this solution were added pyridine (18.7mlitre, 0.22mol) and trifluoroacetic anhydride (24mlitre, 0.17mol). The reaction mixture was stirred at room temperature for 6 hours, diluted with 300mlitre of dichloromethane, and then washed twice with 150mlitre of 5% HCl. The dichloromethane layer was dried over anhydrous magnesium sulfate, and concentrated to obtain 15g of N-trifluoroacetyl-2-methyl-indoline. Yield: 85%

The synthetic route of 6872-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD.; EP1021437; (2001); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem