Related Products of 3891-07-4,Some common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, molecular formula is C10H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1 (2.0 g, 1.05 mmol)And compound 2 (2.3g, 1.7mmol)Add to DMA (20ml) solution,Heat the solution to 40 C,Then slowly add sodium tert-butoxide (1.6 g, 1.6 mmol),The reaction was stirred at 40 C for 3 hours.After the reaction is completed, cool to room temperature.Then slowly add acetic acid to adjust the pH to about 7,Add 10ml of water,Extracted with dichloromethane (50ml × 3),Combined organic phases,Dried over anhydrous sodium sulfate,The concentrated solution was subjected to column separation (eluent: petroleum ether / ethyl acetate (v / v) = 10: 1),To give 2.1 g of a white solid,The yield was 72%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Hydroxyethyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Liu Zhiqiang; Li Huanyin; (38 pag.)CN110317211; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem