2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: indolines-derivatives
General procedure: To a hot stirred solution of the key intermediates 3a, b (0.27 gm,1 mmol) and sodium acetate (0.16 gm, 2 mmol) in acetic acid(15 mL), N-substituted isatins 6a-f were added and this mixturewas heated under reflux for 3 h. The formed solidwas filtered whilehot, dried and recrystallized from DMF/ethanol to obtain the targetcompounds 7a-g.
The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; Gratteri, Paola; Eissa, Ibrahim H.; Fares, Mohamed; Ismael, Omnia E.; Ghabbour, Hazem A.; Elaasser, Mahmoud M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 250 – 262;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem