Related Products of 3339-73-9, A common heterocyclic compound, 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, molecular formula is C11H9NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3-(1,3-dioxoisoindolin-2-yl)propanoic acid (256 mg, 1.17 mmol) in CH2Cl2 (5.9mL) were added (COCl)2 (200 L, 2.33 mmol) and DMF (1 drop) at 0 C.The reaction mixture was stirred at 0 C for 30 min and at room temperature for 3 h. Thesolvents were removed under reduced pressure. Azeotropic distillations were carried out withtoluene (2 × 3 mL) under reduced pressure. The residue (acid chloride) was used for next stepwithout further purification
The synthetic route of 3339-73-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Natori, Yoshihiro; Hwang, Candy S.; Lin, Lucy; Smith, Lauren C.; Zhou, Bin; Janda, Kim D.; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1020 – 1031;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem