Application of 40314-06-5, The chemical industry reduces the impact on the environment during synthesis 40314-06-5, name is 5-Methylisoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.
Isolation and analytic data for 13, observed in the crossover study, was obtained by independent preparation using the following procedure. Isovaleryl chloride (65 muL, 0.53 mmol) was added to a mixture of 4-methylphthalimide (200 mg, 1.2 mmol), isobutyraldehyde (108 muL, 1.19 mmol), NaI (170 mg, 1.1 mmol), 4 A MS (100 mg), triethylamine (150 muL, 1.1 mmol), ethyl acetate (1.1 mL), and acetonitrile (1.1 mL) at room temperature and with stirring. After 24 h, the mixture was diluted in EtOAc and washed with 1 M NaOH (3×) and brine. The organic phase was dried (MgSO4) and concentrated. Purification by flash chromatography (SiO2, hexanes:EtOAc 4:1) gave 13 (105 mg, 0.33 mmol, 62%) as a white solid. 1H NMR (300 MHz, CDCl3): delta 7.76 (d, J=7.6Hz, 1H), 7.68 (s, 1H), 7.55 (d, J=7.6Hz, 1H), 6.19 (d, J=10.4Hz, 1H), 2.90 (nfom, 1H), 2.52 (s, 3H), 2.23 (d, J=7.3Hz, 2H), 2.09 (septet, J=6.7Hz, 1H), 1.08 (d, J=6.6Hz, 3H), 0.91 (d, J=6.6Hz, 3H), 0.90 (d, J=7Hz, 3H), and 0.88 (d, J=7.6Hz, 3H). 13C NMR (75 MHz, CDCl3): delta 171.9, 167.1, 166.9, 145.8, 135.0, 131.8, 128.9, 124.2, 123.6, 79.1, 43.1, 29.5, 25.6, 22.3, 22.1, 19.0, and 17.9. IR (neat): 2963, 2875, 1779, 1748, 1721, 1618, 1468, 1430, 1363, 1101, and 1006 cm-1. HRMS (ESI-TOF): Calcd for C18H23NNaO4+ [M+Na+] requires 340.1519; found 340.1522. Mp: 53-55 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Enright, Robert N.; Grinde, Jeffrey L.; Wurtz, Lincoln I.; Paeth, Matthew S.; Wittman, Tekoa R.; Cliff, Emily R.; Sankari, Yessra T.; Henningsen, Lucas T.; Tan, Chuchen; Scanlon, Joseph D.; Willoughby, Patrick H.; Tetrahedron; vol. 72; 41; (2016); p. 6397 – 6408;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem