Adding a certain compound to certain chemical reactions, such as: 7147-90-2, name is 5-Chloroisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7147-90-2, Quality Control of 5-Chloroisoindoline-1,3-dione
4- Chlorophthalimide (273 mg) is dissolved in a minimum of boiling ethanol (ca. 2.5 ml). 37% formaldehyde solution (0.15 ml) is added to the still hot solution followed by /V-(4-chlorophenyl)glycine (279 mg). Reflux is continued for 3 h. The yellow solution is kept in the refrigerator overnight. The yellow precipitate is collected by suction filtration, washed with ethanol, and dried in vacuo. The crude is recrystallised from ethanol to provide /V-[(5-chloro-l,3-dioxo-2-isondolinyl)methyl]- /V-(4-chlorophenyl)glycine (135 mg) as light yellow crystals. 1H-NMR (500 MHz, DMSOcI6): delta (ppm) = 4.26 (s, 2H), 5.24 (s, 2H), 6.97 (d, J = 9.1 Hz, 2H), 7.22 (d, J = 9.1 Hz, 2H), 7.90 (d, J = 1.2 Hz, 2H), 7.97 (t, J = 1.2 Hz, IH), 12.71 (br s, IH).13C-NMR and DEPT (125 MHz, DMSOd6) : delta (ppm) = 51.77 (CH2), 54.72 (CH2), 114.39 (2 CH), 121.70 (C), 123.35 (CH), 124.99 (CH), 128.39 (2 CH), 129.97 (C), 133.41 (C), 134.38 (CH), 139.41 (C), 145.34 (C), 167.01 (CO), 167.35 (CO), 171.48 (CO). MS ( + ESI): m/z = 379 (M + H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloroisoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem