Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 611-09-6, name is 5-Nitroindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Nitroindoline-2,3-dione
Example 17 (S)-3,5-Dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)- phenyl)-2-(2-(5-(methylsulfonamido)-2,3-dioxoindolin-1 -yl)acetoxy)ethyl)- pyridine 1 -oxide (Compound 99) Scheme 17 Step 1. Preparation of 5,5-dimethyl-5′-nitrospiro[[1 ,3]dioxane-2,3′- indolin]-2′-one (94) A mixture of 5-nitroindoline-2,3-dione (305 mg, 1 .587 mmol), 2,2-dimethylpropane-1 ,3-diol (165 mg, 1 .587 mmol) and p-toluenesulfonic acid monohydrate (catalytic amount) in cyclohexane (9 ml) was stirred at reflux temperature (removing water by a Dean-Stark apparatus) for 6 hours. The reaction was cooled to room temperature and the solid was recovered by filtration and washed with petroleum ether, affording 5,5-dimethyl-5′-nitrospiro[[1 ,3]dioxane-2,3′-indolin]-2′- one (481 mg). that was used as such in the following step. MS/EST 279.0 [MH]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 611-09-6.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; CARZANIGA, Laura; LA PORTA, Elena; GUALA, Matilde; WO2013/57013; (2013); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem