Synthetic Route of 2436-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 1.A solution of 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4- d][l,3]dioxol-4-yl)-9H-purin-6-amine (400 mg, 1.3 mmol) and 3-(l,3-dioxoisoindolin-2- yl)propanal (293 mg, crude 1.44mmol) in DCE (8 mL) were stirred at rt for 0.5 h, then NaBH(OAc)3 (416 mg, 1.96 mmol) was added. The reaction was stirred at rt overnight. The reaction was quenched with aqu. sat. NaHC03 (2 mL), extracted with DCM (10 mLx3), washed with brine (10 mL), dried and concentrated. The residue was purified by prep-TLC (DCM : MeOH = 10 : 1) to the title compound (350 mg, Yield 43%). NMR (500 MHz, MeOD): delta 8.28 (s, 1H), 8.21 (s, 1H), 7.83-7.76 (m, 4H), 6.14(d, J = 3.5 Hz, 1H), 5.46-5.44 (m, 1H ), 5.01-4.99 (m, 1H), 4.32 (br s, 1H), 3.65-3.62 (m, 2H), 2.85-2.83 (m, 2H), 2.57-2.53 (m, 2H), 1.79-1.76 (m, 2H), 1.58 (s, 3H), 1.37 (s, 3H) ppm; ESI-MS (m/z): 494.2[M+1]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(1,3-Dioxoisoindolin-2-yl)propanal, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.; WO2012/82436; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem