Application of 1074-82-4, These common heterocyclic compound, 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of potassium 1,3-dioxoisoindolin-2-ide (125.0 g, 678.1 mmol) in DMF (500 mL) was added 1-chloropropan-2-one (57 g, 594.0 mmol), the reaction mixture was stirred at ambient temperature for about 60 h. The reaction mixture was poured into ice water (1.0 L), the resulting mixture was stirred for about 1 h. The precipitate was collected by filtration and dried in vacuum to afford the product as a white solid (101.2 g, 8 1.3%). MS (ESI, m/e) [M+1] 203.9.
The synthetic route of 1074-82-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BEIGENE, LTD.; WANG, Zhiwei; GUO, Yunhang; YU, Desheng; (98 pag.)WO2019/34009; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem