Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, A new synthetic method of this compound is introduced below., Formula: C11H9NO3
A solution of 7a (30.1 mg, 0.15 mmol, 1.5 eq) and (S)-10 (0.6 mg, 0.001 mmol, 0.01 eq) was stirred atroom temperature in anhydrous THF (2 mL) for 30 min before adding NFSI (31.2 mg, 0.01 mmol,1 eq). The reaction mixture was then stirred at room temperature for 6 h, then pentane was added andthe precipitate was filtered off. The residue was concentrated and then dissolved in MeOH (2 mL),NaBH4 (1 mmol) was added and stirred for 1 h at room temperature. The reaction was quenched with(1M, 2 mL) aqueous solution of KHSO4, (2 mL) water was added and the aqueous layer was extractedwith EtOAc (3 5 mL), the organic layers was collected and dried over MgSO4 and evaporated invacuo. The crude compound was subjected to silica gel column (98%-90% hexane/EtOAc) to give thetitle compound as colourless oil;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Cheerlavancha, Raju; Ahmed, Ahmed; Leung, Yun Cheuk; Lawer, Aggie; Liu, Qing-Quan; Cagnes, Marina; Jang, Hee-Chan; Hu, Xiang-Guo; Hunter, Luke; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2316 – 2325;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem