Electric Literature of 5394-18-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2-(4-bromobutyl)isoindoline-l,3-dione (3.33 g, 11.8 mmol), tert- butyl piperazine-l-carboxylate (2.2 g, 11.8 mmol) and Et3N (4.9 ml, 35.4 mmol) in CH3CN (50 mL) is heated at reflux for 16 h. The mixture is cooled and the solvent is evaporated. The residue is partitioned between EtOAc (70 mL) and water (70 mL). The organic layer is washed with brine (40 mL), dried (Na2S04) and evaporated. The residue is purified by flash column with 1:1 Hexane/EtOAc gives colorless oil (3.91 g, 85%).’HNMR (CDCI3,) delta: 7.83 (dd, 2H), 7,71 (dd, 2H), 3.71 (t, 2H), 3.41 (t, 4H), 2.34- 2.38 (m, 6H), 1.67-1.70 (m, 2H), 1.50-1.56 (m, 2H), 1.45 (s, 9H).LC-MS M+1: 388.12;
The chemical industry reduces the impact on the environment during synthesis 2-(4-Bromobutyl)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; HAN, Bingsong; KUNTZ, Judith D.; LIN, Jian; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZHENG, Xiaozhang; WO2012/154194; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem