Some common heterocyclic compound, 875003-43-3, name is 7-Fluoro-1-methylindoline-2,3-dione, molecular formula is C9H6FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: indolines-derivatives
20.64 mg of N-methyl-7-fluoroisidine, 27.22 mg (28.06 mL) of trimethyl orthoformate and an appropriate amount of phosphotungstic acid were charged in a IOOmL flask, and the mixture was stirred at room temperature with Thin layer chromatography to determine whether there is a new product generation and tracking the progress of the reaction, the reaction is complete, add appropriate amount of triethylamine neutralization reaction to neutral, the reaction is complete after the reaction solution evaporated under pressure, the concentrate water, solid matter Precipitation, filtration, washing filter cake, the target product to obtain crude products, recrystallization can be pure target products.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 875003-43-3, its application will become more common.
Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Jia Minyi; Song Huihui; (15 pag.)CN106632365; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem