Application of 496-12-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 496-12-8, name is Isoindoline, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2,3-dihydro-1 H-isoindole (0.3 mL) in dichloromethane (5 mL)Triethylamine (0.7 mL)And the mixture was ice-cooled to 0 C.,2-Bromoacetyl bromide (0.4 mL) was added dropwise, followed by stirring at room temperature for 18 hours.Water was added to the reaction solution, the mixture was extracted with dichloromethane and washed with saturated brine.The organic layer was dried over sodium sulfate and the solvent was distilled off under reduced pressure to obtain a residue.Purification by silica gel column chromatography (hexane-ethyl acetate)2-Bromo-1- (2,3-dihydro-1 H-isoindol-2-yl)Ethan-1-one281 mg (yield 47%) was obtained.
The chemical industry reduces the impact on the environment during synthesis Isoindoline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY; YANAGISAWA, KATSUHIKO; KAWAI, AKIYOSHI; (139 pag.)JP2017/171619; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem