Reference of 603-62-3, A common heterocyclic compound, 603-62-3, name is 3-Nitrophthalimide, molecular formula is C8H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The preparation of 2-amino-6-nitrobenzoic acid was carried out in accordance with the literature (R. Kahn, Chem. Ber. 1902, 35, 3857-3884; W. S. Saari, J. E. Schwering, J. Heterocycl. Chem. 1986, 23, 1253-1255) via regioselective opening of 3-nitrophthalimide with aqueous potassium hydroxide to give phthalamic acid and subsequent Hofmann degradation with sodium hypobromite to give the 2-amino-6-nitrobenzoic acid.
The synthetic route of 603-62-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gruenenthal GmbH; US2008/293749; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem