Related Products of 2518-24-3, A common heterocyclic compound, 2518-24-3, name is 4-Aminoisoindoline-1,3-dione, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Aminoisoindoline-1,3-dione (2, 2.00 g, 12.3 mmol) was dissolved in MeOH(200 mL), and the solution was treated with N-bromosuccinimide (2.19 g,12.3 mmol). The reaction was stirred at room temperature for 50 min. The solid thatprecipitated was collected by filtration and washed with MeOH to give bromide 3(2.21 g, 9.21 mmol, 75%) as a yellow powder, mp 287-289C. 1H NMR (DMSOd6):d 11.1 (s, 1H), 7.51 (d, J D 8.9 Hz, 1H), 6.90 (d, J D 8.9 Hz, 1H), 6.53 (br s,2H); 13C NMR (DMSO-d6): d 170.0, 167.7, 146.5, 139.6, 130.2, 123.6, 112.4, 101.6;MS: m/z 240, 242 (C8H5BrN2O2, MC¢, ca. 1:1).Anal. Calcd for C8H5BrN2O2: C, 42.51; H, 1.78; N, 6.20. Found: C, 42.63; H, 1.86;N, 6.14.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gnanasekaran, Krishna Kumar; Rivera, Mario; Bunce, Richard A.; Organic Preparations and Procedures International; vol. 50; 3; (2018); p. 372 – 374;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem