Related Products of 118289-55-7, The chemical industry reduces the impact on the environment during synthesis 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, I believe this compound will play a more active role in future production and life.
Example 15 5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride A mixture of 6-chloro-5-(2-chloroethyl)indolin-2-one (332 mg, 1.45 mmol), the product of Reference Example 1 (370 mg, 1.45 mmol), sodium carbonate (461 mg, 4.35 mmol), iodine sodium (216 mg, 1.45 mmol) and water (5 ml) was stirred under reflux for 24 hours. The reaction was cooled to room temperature, extracted with methylene chloride and water. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated and subjected to column chromatography to obtain an oil. Hydrogen chloride-ethanol solution was added thereto under stirring, the resulting salt was slurried in isopropanol, filtered to give a pale yellow solid (308 mg, yield: 51%). 1HNMR (400 MHz, DMSO-d6): delta ppm 11.04 (brs, 1H), 10.55 (s, 1H), 7.77 (d, 1H), 7.71 (d, 1H), 7.50 (d, 1H), 7.32 (t, 1H), 7.29 (s, 1H), 6.98 (d, 1H), 6.88 (s, 1H), 3.71 (d, 2H), 3.57 (d, 2H), 3.50 (s, 2H), 3.38 (m, 4H), 3.21 (m, 4H). ESI-MS (m/z): 412.2 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloro-5-(2-chloroethyl)indolin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem