Analyzing the synthesis route of 17630-75-0

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17630-75-0 as follows. Quality Control of 5-Chloro-2-oxindole

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17630-75-0 as follows. Quality Control of 5-Chloro-2-oxindole

A mixture of 5-chlorooxindole (6.98 g, 41.6 mmol), 3,5-dimethyl-1H-pyrrole-2-carboxaldehyde (5.12 g, 41.6 mmol) and piperidine (410 muL, 4.16 mmol) in 200 mL of EtOH was heated at reflux for 8 h. The reaction mixture was cooled to room temperature and filtered to give the title compound (4.50 g, 40%) as a red/orange solid.

According to the analysis of related databases, 17630-75-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Allergan, Inc.; US2004/102509; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem