Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1914-02-9, name is 3,3-Dimethylindoline, A new synthetic method of this compound is introduced below., Formula: C10H13N
A mixture of 3,3-dimethylindoline (5s, 103 mg, 0.700 mmol), potassium carbonate (288 mg,2.084 mmol), and 2-bromopropanenitrile (303 muL, 3.506 mmol) in 2 mL CH3CN was stirred at 80C overnight. The mixture was concentrated and purified by preparative HPLC. Fractions containing productwere partly concentrated and residue was extracted with 1 M NaHCO3 and CH2Cl2. Organic phases weredried over MgSO4, filtered, and concentrated to give 2-(3,3-dimethylindolin-1-yl)propanenitrile (105mg). LCMS m/z = 201.2 [M+1]+; 1H NMR (400 MHz, CDCl3) delta ppm 1.26 (s, 3H), 1.40 (s, 3H), 1.63 (d, J = 7.3Hz, 3H), 3.05 (d, 1H, J = 8.2 Hz), 3.25 (d, 1H, J = 8.2 Hz), 4.57 (q, 1 H, J = 7.3 Hz), 6.57 (d, 1H, J = 7.9 Hz),6.83-6.87 (m, 1H), 7.06 (dd, 1H, J1 =7.4 Hz, J2 = 0.8 Hz), 7.12-7.16 (m, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Dang, Huong; Feichtinger, Konrad; Frazer, John; Grottick, Andrew J.; Kasem, Michelle; Le, Minh; Lehman, Juerg; Morgan, Michael E.; Ren, Albert; Sage, Carleton R.; Schrader, Thomas O.; Semple, Graeme; Unett, David J.; Whelan, Kevin T.; Wong, Amy; Zhu, Xiuwen; Bioorganic and medicinal chemistry letters; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem