Reference of 32372-82-0, These common heterocyclic compound, 32372-82-0, name is Isoindoline hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
l-Ethyl-3-(3- dimethylaminopropyl)carbodiimide (2 eq.) was added to a stirred solution of 30 (1 eq.), isoindoline hydrochloride (1.5 eq.), 1- hydroxybenzotriazole (2 eq.) N,N-diisopropylethylamine (2 eq.) in dichloromethane (150 mL) at 0 C. The resulting solution was stirred at room temperature for 14 h before quenching with saturated sodium bicarbonate solution (120 mL). The organic layer was washed with 1 M hydrochloric acid solution (120 mL) and saturated sodium chloride solution (120 mL), dried over sodium sulfate, filtered, and concentrated. The residue was purified by flash chromatography (Si02, 1 :4 hexanes/ethyl acetate) to afford 31 (82%) as a white amorphous solid. 1H- NMR (500 MHz, CDC13) delta 8.06 (s, 1H), 7.43 (m, 2H), 7.37 (m, 2H), 5.32 (s, 1H), 5.01 (t, 1H), 4.46 (s, 4H), 3.87 (s, 3H), 3.11 (m, 2H), 2.06 (m, 2H).13C-NMR (125 MHz, CDC13) delta 169.5, 156.6, 143.9, 140.0 (2), 132.8, 129.1, 126.2 (2), 126.2 (2), 115.3, 61.9, 56.1 (2), 35.2, 19.7.
Statistics shows that Isoindoline hydrochloride is playing an increasingly important role. we look forward to future research findings about 32372-82-0.
Reference:
Patent; UNIVERSITY OF KANSAS; BLAGG, Brian S. J.; KENT, Caitlin Nicole; MISHRA, Sanket Jaiprakash; (93 pag.)WO2018/132769; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem