Adding a certain compound to certain chemical reactions, such as: 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118289-55-7, Quality Control of 6-Chloro-5-(2-chloroethyl)indolin-2-one
8. Preparation of ZPR in glycerol by Na C03 portion-wise addition To a three necked flask was charged BITP HC1 (15g), CEI (16. 2g), glycerol (60ml) and Na2C03 (3. 11 g, 0. 5mol). The reaction mixture was heated at 115 C and after 15′ a new portion of 0.12 mol Na2C03 was added. The heating was continued by addition of 0.12 mol base each hour. After 5 hours the base addition was completed and the reaction mixture was heated for an additional hour. After cooling to room temperature, the mixture was diluted with water (120ml) and after 1 hour stirring the product crude was filtrated, washed with water and dried at 50C to afford 25.7g dried product (yield 82. 4%) (purity by HPLC 94%).
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Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/40160; (2005); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem