Reference of 496-12-8, A common heterocyclic compound, 496-12-8, name is Isoindoline, molecular formula is C8H9N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Conc. H2SO4 (8 mL) was added dropwise at 0 C to a solution ofisoindoline (19) (2 g) in DCM (10 mL), and the reaction mixturewasstirred at rt for 10 min. DCM was evaporated under vacuum fromthe reaction mixture and conc. HNO3 (2 mL) was added dropwise at0 C. The reaction mixture was stirred for 2 h at rt. Ice water wasadded to the reaction mixture then the reaction mixture wasbasified with sodium bicarbonate. Extraction was done with EtOAc(100 mL x 3) and the combined organic layer was dried overanhydrous MgSO4 and concentrated under reduced pressure to give 20 in 50% yield; 1H NMR (300 MHz, CDCl3): d 8.07e8.12 (m, 2 H),7.34 (d, J 8.5 Hz, 1H), 4.32 (s, 4H).
The synthetic route of 496-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ojha, Ritu; Nepali, Kunal; Chen, Chun-Han; Chuang, Kuo-Hsiang; Wu, Tung-Yun; Lin, Tony Eight; Hsu, Kai-Cheng; Chao, Min-Wu; Lai, Mei-Jung; Lin, Mei-Hsiang; Huang, Han-Li; Chang, Chao-Di; Pan, Shiow-Lin; Chen, Mei-Chuan; Liou, Jing-Ping; European Journal of Medicinal Chemistry; vol. 190; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem