Adding a certain compound to certain chemical reactions, such as: 60434-13-1, name is 5-Chloro-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60434-13-1, Computed Properties of C9H6ClNO2
General procedure: A solution of N-methylisatin (161 mg, 1.0 mmol), N-methylindole (262 mg, 2.0 mmol), and p-TsOH . H 2 O (19 mg, 0.1 mmol) in CH 2 Cl 2 (2.0 mL) was stirred at room temperature for 1 h. After aqueous extractive workup and column chromatographic purification process (n-hexane/EtOAc, 2:1), 1a was obtained as a white solid, 301 mg (74%). 1 Other compounds 1b-f, 1i, 1j, and 1n were synthesized similarly, and compounds 1a1 and 1n1 are known compounds. The spectroscopic data of unknown compounds 1b-f, 1i, and 1j are as follows.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-1-methylindoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Article; Seo, Da Young; Kim, Gieun; Jo, Hwi Yul; Kim, Jae Nyoung; Bulletin of the Korean Chemical Society; vol. 39; 4; (2018); p. 587 – 590;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem