Application of 2058-72-2, These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of isatoic anhydride 1 (1 mmol), isatin 2 (1 mmol), phenyl hydrazine 3 (1 mmol), 0.3 g (0.6 mmol) alum, and 10 ml EtOH in a 50 ml flask was stirred at reflux for time period asindicated in Table 1. After completion of the reaction (monitored by TLC, ethylacetate/n-hexane,1:1), 25 ml EtOH was added to the reaction mixture, and recrystallized from ethanol to afford pure product.
Statistics shows that 5-Bromo-1-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 2058-72-2.
Reference:
Article; Mohammadi, Ali A.; Askari, Saber; Rohi, Hamed; Soorki, Ali Abolhasani; Synthetic Communications; vol. 44; 4; (2014); p. 457 – 467;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem