Reference of 317-20-4, These common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Potassium hydroxide (1.58 g; 28.16 mmol; 3.10 eq.) was added portion wise to a solution of 7-Fluoro-1H-indole-2,3-dione (1.50 g; 9.08 mmol; 1.00 eq.) in acetone (1.00 ml; 13.63 mmol; 1.50 eq.), ethanol (4.50 ml) and water (1.50 ml) in a microwave tube. The reaction was placed in a microwave oven and heated at 100 C. for 20 min. The reaction mixture was concentrated under vacuum. Water was added followed by a 5N solution of hydrochloric acid until the pH of the solution reached 4. The suspension was then filtered and the solid obtained dried. 8-fluoro-2-methylquinoline-4-carboxylic acid (1.60 g; 85.84%) was isolated as a brown solid
Statistics shows that 7-Fluoroisatin is playing an increasingly important role. we look forward to future research findings about 317-20-4.
Reference:
Patent; GALDERMA RESEARCH & DEVELOPMENT; OUVRY, Gilles; HARRIS, Craig Steven; BHURRUTH-ALCOR, Yushma; (65 pag.)US2017/247353; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem