Related Products of 13861-75-1, The chemical industry reduces the impact on the environment during synthesis 13861-75-1, name is Spiro[cyclopropane-1,3′-indolin]-2′-one, I believe this compound will play a more active role in future production and life.
EXAMPLE 5 N-(1-azabicyclo[2.2.2]octan-4-ylmethyl)-2′-oxo-spiro[cyclopropane-1,3′-[3’H]indole]-1′(2’H)-carboxamide, monohydrochloride STR13 To sodium hydride (92 mg, 2.31 mmol) (washed 2* with hexane) suspended in THF (1 ml) was added spiro[cyclopropane-1,3′-[3’H]indol]-2′(1’H)-one (92 mg, 0.578 mmol) and the reaction was stirred for 5 minutes. The resulting suspension was added to a solution of 20% phosgene in toluene (2.29 ml, 4.62 mmol) in THF (2 mL) and stirred for 0.5 hour. The reaction mixture was then filtered through celite and concentrated in vacuo to give a beige solid which was dissolved in THF (5 ml) and treated with a solution of 4-aminomethyl quinuclidine (81 mg, 0.578 mmol) as prepared in Example A in THF (2 ml) and stirred for 18 hours. Concentration in vacuo gave a solid which was dissolved in chloroform, washed with 1N NaOH solution, dried over K2 CO3, filtered and concentrated in vacuo to give the crude desired compound as a solid. Purification on silica gel eluding with 10% CH3 OH(NH3)/CHCl3 gave the title compound (35 mg, 19%). The free base (59 mg, 0.181 mmole) was converted to the hydrochloride salt by treatment with methanolic HCl to give the monohydrochloride (57 mg, 91%) as a solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Spiro[cyclopropane-1,3′-indolin]-2′-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; G. D. Searle & Co.; US5399562; (1995); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem