Reference of 56341-37-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56341-37-8, name is 6-Chlorooxindole, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 11 (FROM TABLE 3) 3-[5-(6-Chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrol-3-yl]-propionic acid 4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (200 mg), 167.6 mg 6-chloro-2-oxindole, and 166 muL piperidine in 2 mL of ethanol were heated at 95 C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven to give 246 mg (74%) of the title compound as a brown solid. 1H-NMR (360 MHz, DMSO-d6): delta 13.22 (s, br, 1H, NH-1′), 12.09 (s, br, 1H, COOH), 10.95 (s, br, 1H, NH-1), 7.78 (d, J=7.95 Hz, 1H, H-4), 7.66 (s, 1H, H-vinyl), 7.18 (d, J=2.64 Hz, 1H, H-2′), 7.01 (dd, J=1.90, 7.95 Hz, 1H, H-5), 6.86 (d, J=1.90 Hz, 1H, H-7), 2.65 (t, J=7.14 Hz, 2H, CH2CH2COOH), 2.45 (t, J=7.14 Hz, 2H, CH2CH2COOH), 2.26 (s, 3H, CH3).
The chemical industry reduces the impact on the environment during synthesis 6-Chlorooxindole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sugen, Inc.; US6878733; (2005); B1;,
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