In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5428-09-1 as follows. name: 2-Allylisoindoline-1,3-dione
The title compound was prepared by utilising Ni(dppp)Br2 (32 mg,50.0 mumol, 10 mol%), zinc powder (6.6 mg) and zinc iodide (32 mg,100 mumol, 20 mol% each). These materials were suspended in dichloromethane(0.3 mL) then Ph2PH solution (0.125 M in dichloromethane,0.2 mL, 25.0 mumol, 5 mol%) was added. 2-Allylisoindoline-1,3-dione (94 mg, 0.502 mmol, 1.0 equiv) was added at ambient temperatureand the reaction mixture was stirred for 18 h. Workup accordingto the general procedure and purification by flash columnchromatography (n-pentane/tert-butyl methyl ether, 20:1) gave 6d asa single E-isomer. Yield: 80 mg (0.426 mmol, 85%); yellow solid.1H NMR (300 MHz, CDCl3): delta = 7.87-7.83 (m, 2 H), 7.75-7.70 (m, 2 H),6.64-6.53 (m, 2 H), 1.84 (d, J = 5.0 Hz, 3 H).13C NMR (76 MHz, CDCl3): delta = 168.8, 134.4, 131.9, 123.6, 118.5, 118.3,16.4.
According to the analysis of related databases, 5428-09-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Weber, Felicia; Steinlandt, Philipp S.; Ballmann, Monika; Hilt, Gerhard; Synthesis; vol. 49; 2; (2017); p. 440 – 450;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem