Related Products of 552330-86-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 552330-86-6, name is 5-Bromoisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows.
B. 5-(4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)isoindolin-l-one. Bis (pinacolato)diboron (815 mg, 3.21 mmol), dichloro[ 1 , 1 ‘-bis(diphenylphosphino) ferrocene]palladium (II) dichloromethane (240 mg, 0.29 mmol) and potassium acetate (860 mg, 8.76 mmol) were successively added to a solution of 5-bromoisoindolin-l-one (620 mg, 2.92 mmol) in methylene chloride (15 mL), followed by DMSO (5 mL). ). The resulting reaction mixture was heated at 100 C for 4h. Upon cooling, the crude mixture was diluted with water, extracted with methylene chloride (3x); the combined organic fractions were washed with water, brine, dried over magnesium sulfate, filtered, and the volatiles were removed under reduced pressure. The crude product was taken into hexanes, sonicated, and the precipitate was collected by filtration to afford the desired product (250 mg, 33%). MS (ESI) m/z 260.3 [M+ 1]+.
The chemical industry reduces the impact on the environment during synthesis 5-Bromoisoindolin-1-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2008/51493; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem